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Tripterygium wilfordii multiglycoside-induced hepatotoxicity via inflammation and apoptosis in zebra
Tripterygium wilfordii multiglycoside(GTW)is a commonly used compound for the treatment of rheumatoid arthritis(RA)and i......
目的可溶性mPDL1-hIgGFc(mouse PDL1-human IgG Fc)表达载体的构建与表达,及其对诱导细胞增殖与凋亡的研究。方法以含有mPDL1基因的载......
目的 探讨当归多糖ASP3对小鼠肝细胞培养液辐照后凋亡相关基因bcl-2和bax的蛋白表达的影响.方法 以当归多糖的自制提取物ASP3为受......
目的:通过观察ip丙泊酚对脑缺血再灌注大鼠海马区神经细胞的影响,探讨丙泊酚对临床围手术期预防脑缺血再灌注损伤的作用。方法 SD大......
Anti-cancer effects of COX-2 inhibitors and their correlation wit angiogenesis and invasion in gastr
AIM:To observe the anti-cancer effects of COX-2 inhibitorsand investigate the relationship between COX-2 inhibitorsand ......
目的 探究慢性脑低灌注大鼠海马神经元损伤的机制.方法 双侧颈总动脉结扎(2VO)制备慢性脑低灌注大鼠模型,2VO术后8周取材,分别进行......
Objective:To investigate the impact of acute lifestyle changes on human sperm functional quality.Methods:In the academic......
Effects of Electroacupuncture on Hippocampal and Cortical Apoptosis in A Mouse Model of Cerebral Isc
Objective: To observe the effects of electroacupuncture on hippocampal and cortical apoptosis in a mouse model of cerebr......
目的探讨非诺贝特干预对大鼠颅脑损伤后脑组织中NF-κB p65、IL-6和细胞凋亡的变化及其可能机制。方法98只健康雄性SD大鼠按随机数......
目的浅析依达拉奉对颈脊髓受压节段神经元凋亡的影响。方法组Ⅰ(空白对照)、组Ⅱ(依达拉奉治疗)两组各150只兔子。颈后正中入路金......
目的探讨血必净注射液对体外循环(CPB)致急性肺损伤(ALI)的防治作用及机制。方法①体内实验:将30只成年雄性SD大鼠按随机数字表法分为假......
Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell
AIM: To evaluate the expression of fragile histidine triad (FHIT) gene protein, product of a candidate tumor suppressor,......
目的探讨高迁移率族蛋白1(HMGB1)对耐吉西他滨的胰腺癌PANC1细胞耐药性的作用和可能机制。方法采用浓度梯度递增诱导法建立耐吉西......
AIM: To investigate the effect of curcumin on tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in rat cortical......
目的:研究雌激素干预对急性一氧化碳(CO)中毒迟发性脑病(DNS)的防治作用,探索有效的临床治疗手段。方法:选择成年Wistar雌性大鼠。......
,Peroxisome proliferator-activated receptor γ ligands induce cell cycle arrest and apoptosis in huma
Aim: To study the effect of peroxisome proliferator-actived receptor γ (PPARγ)ligands on cell proliferation and apopto......
,Tumor suppressor in lung cancer-1 (TSLC1) mediated by dual-regulated oncolytic adenovirus exerts sp
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,Sodium tanshinone IIA sulfonate protects rat myocardium against ischemia-reperfusion injury via act
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,Y-Secretase inhibitor DAPT sensitizes t-AUCB-induced apoptosis of human glioblastoma cells in vitro
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,Dual anti-ischemic effects of rosmarinic acid n-butyl ester via alleviation of DAPK-p53-mediated ne
The discovery of efficacious anti-ischemic drugs remains a challenge.Recently we have found that rosmarinic acid n-butyl......
目的:探讨葫芦素I对肝癌细胞生长的抑制作用及机制.方法:采用CCK-8法检测葫芦素I对不同肝癌细胞(HepG2、QGY-7703、SMMC-7721)增殖......
目的探讨沉默 Caveolin-1(Cav-1)基因对人膀胱癌细胞株5637增殖和凋亡的影响。方法通过siRNA转染人膀胱癌细胞株5637(沉默组),以转......
Effect of Chronic Noise Exposure on Expression of N-Methyl-D-Aspartic Acid Receptor 2B and Tau Phosp
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Effects of Panax notoginseng saponins on hydrogen peroxide-induced apoptosis in cultured rabbit bone
Objective To investigate the effects of Panax notoginseng saponins (PNS) on hydrogen peroxide (H2O2)-induced apoptosis i......
目的 探讨高强度超声对环氧化酶-2( COX-2) mRNA的表达及其影响乳腺癌MDA-MB-231细胞凋亡的作用机制.方法 用高强度超声(50 w/cm2)......
目的 探讨外周血单个核细胞凋亡(PBMC)和Th 1/Th 2型细胞因子表达在乙型肝炎病毒慢性化中的作用.方法 分离21例健康人、45例慢性乙......
The study of RNAi-mediated by conditionally replicating adenovirus silencing on Survivin gene in col
Objective: To investigate the effect of RNAi-mediated Survivin gene with conditionally replicating adenovirus silencing ......
目的 将胚胎后肾间充质细胞移植到大鼠右肾包膜下,探讨移植细胞对宿主急性肾小管坏死(ATN)的保护作用.方法 体质量相近的SD大鼠按......
目的 探讨叠氮胸苷(AZT)对TJ905 人胶质母细胞瘤细胞株端粒酶活性、增殖和凋亡的影响及其机制.方法 体外培养TJ905细胞分别经50、1......
目的 观察生酮饮食对幼鼠颅脑损伤后继发性脑损伤的保护作用.方法 应用Feeney自由落体模型制造局灶性脑挫伤,外伤后予正常饮食或生......
目的:探讨内质网分子伴侣GRP78在拟老化大鼠耳蜗中的变化,研究老年性聋的发病机制。方法:Wistar大鼠24只,随机分为对照组与模型组,......
目的 观察苏木精对人类膀胱癌T24细胞的杀伤及诱导凋亡的作用,探讨其对靶细胞杀伤的作用机制.方法 将靶细胞培养于含药量分别为0、......
目的 评价糖皮质激素受体在慢性吗啡耐受大鼠脊髓背角神经元凋亡中的作用.方法 鞘内置管成功的健康雄性SD大鼠20只,体重300~350 g,......
目的 通过检测急性脑梗死(acute cerebral infarction,ACI)患者血清可溶性Fas(soluble Fas,sFas)和可溶性Fas配体(soluble Fasliga......
目的 探讨clodronate脂质体的制备及其对重症急性胰腺炎(severe acute pancreatitis,SAP)大鼠腹腔巨噬细胞(peritoneal Macrophage......
Expression of fragile histidine triad in primary hepatocellular carcinoma and its relation with cell
AIM: To evaluate the expression of fragile histidine triad (FHIT) gene protein, product of a candidate tumor suppressor,......
目的 观察Cdx2小分子干扰RNA (Cdx2-siRNA)对人胃癌MGC-803细胞增殖及凋亡的影响.方法 设计合成针对Cdx2基因的siRNA寡核苷酸以及......
目的 动态研究2型糖尿病大鼠肝脏脂质代谢紊乱所致的损伤和细胞凋亡及其与固醇调节组件结合蛋白-1c(SREBP-1c)及C Jun氨基端激酶(J......
目的通过在肾小球足细胞中转染p25基因,探讨周期素依赖性蛋白激酶5(Cdk5)的活性对足细胞结构及功能的影响。方法 2014年度,于含10%......
内质网是细胞内蛋白质、脂类和糖类的重要合成基地,是细胞内钙离子的储存场所,与物质运输、物质交换、解毒作用密切相关。内质网应......
Neuronal apoptosis and neurofilament protein expression in the lateral geniculate body of cats follo
BACKGROUND: The visual pathway have 6 parts, involving optic nerve, optic chiasm, optic tract, lateral geniculate body, ......
目的本研究拟通过干扰新的叶酸相关代谢-核苷三磷酸还原成相应的脱氧核苷三磷酸通路中的关键酶-核苷酸还原酶,诱导构建神经管畸形(......
目的观察豚鼠脑缺血再灌注后葡萄糖结合蛋白(glucose-regulated protein,GRP78)、半胱氨酸天冬氨酸蛋白酶-12(caspase-12)在听皮层的表......
目的观察行瘀清热胶囊对大鼠前列腺成纤维细胞增殖及凋亡的影响。方法取健康SD大鼠前列腺组织进行成纤维细胞的原代培养并传代增殖......
目的 mir-153可负调控阿尔茨海默病(Alzheimer’s disease,AD)主要致病基因APP及APLP2的蛋白表达,降低其胞内降解片段(intracellular ......
目的探讨核因子-кB(NF-κB)抑制剂吡咯烷二硫氨基甲酸(PDTC)与顺铂(DDP)联合应用治疗肺癌的效应及其机制.方法培养人肺癌A549细胞......
目的探讨新型酞菁类光敏剂锌酞菁H1(ZnPcH1)介导的光动力疗法(ZnPcH1-PDT)对鼻咽癌CNE1细胞的杀伤作用。方法采用人鼻咽癌CNE1细胞作为......
应用细胞培养、 ~3H-TdR掺入、 流式细胞和电镜技术, 观察酪氨酸蛋白激酶(PTK)抑制剂genistein对正常大鼠垂体前叶细胞和垂体瘤细胞......
Apoptosishasbeenintensivelystudiedinhepatobiliarydiseases.However,dataabouttherelationshipbetweenlivercirho-sisandapoptosisis.........